Preservation of Chromatin Organization after Acute Loss of CTCF in Mouse Embryonic Stem Cells
Naoki Kubo, Haruhiko Ishii, Xiong Xiong, Simona Bianco, Franz Meitinger, Rong Hu, James D. Hocker, Mattia Conte, David U. Gorkin, Miao Yu, Bin Li, Jesse R. Dixon, Ming Hu, Mario Nicodemi, Huimin Zhao, Bing Ren
This study shows that chromatin organization remains largely intact in mouse embryonic stem cells after acute CTCF depletion, despite reduced cell growth and changes in chromatin loop interactions and cohesin occupancy.
Nature Structural & Molecular Biology · Jan 4, 2021Peer-reviewedGenomics