James D. Hocker

The paper creates a chromatin accessibility atlas across 25 adult human tissues, identifying over 750,000 cis-regulatory elements and linking them to gene regulatory programs and disease-associated variants.

The paper defines cardiac cell type-specific cis-regulatory elements and links disease risk variants to these elements in human hearts.

This study shows that chromatin organization remains largely intact in mouse embryonic stem cells after acute CTCF depletion, despite reduced cell growth and changes in chromatin loop interactions and cohesin occupancy.

This study shows that CTCF depletion in mESCs weakens TAD boundaries and INs but only affects a small subset of enhancer-promoter contacts, highlighting CTCF's role in promoting long-range gene regulation.