Loss of Cdk5rap2 triggers cellular senescence via β-catenin-mediated downregulation of WIP1
Xidi Wang, Patrick Sipila, Zizhen Si, Jesusa L. Rosales, Xu Gao, Ki-Young Lee
This paper shows that loss of Cdk5rap2 causes cellular senescence by reducing WIP1 through β-catenin downregulation via GSK3β activation.
bioRxiv · Jul 9, 2020 · PreprintCell Biology