Sequence-encoded H2A.Z nucleosome dynamics control DNA unwrapping and SUV420H1 recognition
Tong Zhang, L Huang, Xuanfeng Li, Baoguo Liu, Juan Li, Chaowei Shi, Shusheng Fu, Zheng Zhou, ShengQi Xiang
This study shows that H2A.Z's sequence-encoded flexibility in specific regions enhances DNA unwrapping and enables SUV420H1 recognition, revealing a mechanism linking nucleosome dynamics to epigenetic enzyme specificity.
bioRxiv · Jun 11, 2026 · PreprintBiochemistry