Tong Zhang

Discovery of a taxusin-mediated route to baccatin III enables its complete biosynthesis in engineered microbes

The paper identifies a novel biosynthetic pathway for baccatin III production using engineered microbes, achieving its complete de novo synthesis through enzymatic validation and pathway engineering.

Complete elucidation and heterologous reconstruction of the biosynthetic pathway of camptothecin

This study identifies the complete biosynthetic pathway of camptothecin, discovers missing enzymes, and validates the pathway through heterologous reconstruction in yeast.

Sequence-encoded H2A.Z nucleosome dynamics control DNA unwrapping and SUV420H1 recognition

This study shows that H2A.Z's sequence-encoded flexibility in specific regions enhances DNA unwrapping and enables SUV420H1 recognition, revealing a mechanism linking nucleosome dynamics to epigenetic enzyme specificity.

Metabolic dehalogenation of halomethanes by mercury methylators

This study identifies halomethanes as potential substrates for HgcAB, suggesting their role in the evolution of mercury methylation through metabolic dehalogenation.

MERFISH 2.0, an ultra-sensitive single-cell spatial transcriptomics imaging chemistry across diverse tissue types

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

Mutations in PIKFYVE cause autosomal dominant congenital cataract

The paper identifies a mutation in PIKFYVE as a cause of congenital cataract and shows that Baf-A1 treatment alleviates the defect in zebrafish models.

Genome analysis and data sharing informs timing of molecular events in pancreatic neuroendocrine tumour

The paper analyzes genomic data from pancreatic neuroendocrine tumors to identify a widespread copy neutral loss-of-heterozygosity pattern linked to tumor progression and potential therapeutic targets.

Changeover from signalling to energy-provisioning lipids during transition from colostrum to mature milk in the giant panda (Ailuropoda melanoleuca)

The paper examines lipid transitions in giant panda milk from colostrum to mature milk, finding an early provision of signaling lipids followed by a shift to energy-provisioning lipids.

Changes in the milk metabolome of the giant panda (Ailuropoda melanoleuca) with time after birth: Three phases in early lactation and progressive individual differences

This study analyzes changes in the milk metabolome of giant pandas over early lactation, identifying three phases and individual differences, with implications for neonatal development.