ShengQi Xiang

This study shows that HP1α phase separation is driven by interactions between intrinsically disordered regions and folded domains, not just IDRs alone, and reveals how poly-PR affects this process in a concentration-dependent manner.

This study shows that H2A.Z's sequence-encoded flexibility in specific regions enhances DNA unwrapping and enables SUV420H1 recognition, revealing a mechanism linking nucleosome dynamics to epigenetic enzyme specificity.

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

The paper shows that spatial clustering of piRNA genes in nematodes enhances transcription through phase separation involving UAD-2 and the SUMO regulatory factors GEI-17 and TOFU-3.

This study identifies the temperature-dependent phase separation mechanism of HSF1, revealing its molecular basis and species-specific regulation through simulations and experiments.