Dynamic Control of Prokaryotic Chromosome Ploidy Rewires Metabolic Networks to Enhance Product Biosynthesis
Xin Jin, Yaping Gao, Han-nuo Shen, Xuanye Zhang, Xiaomei Xu, Sumeng Wang, Qingsheng Qi, Quanfeng Liang
This paper develops a dynamic polyploid engineering strategy that enhances L-threonine production by coupling chromosome ploidy to metabolic state during fermentation.
bioRxiv · Aug 28, 2026 · PreprintSynthetic Biology