Selective abundance of miR-290-295 in the adult Substantia Nigra dopamine neurons is neuroprotective via preservation of protein synthesis
Zixuan Li, Yang Xu, Nicola Murgia, Rongpu Liu, Ece Taşcı, Nikolay Kovzel, Dick San Ng, Haixia Jiang, Yu Liu, Xuejia Kang, Donglei Sun, Andrii Domanskyi, Wenjie Zhang, Ilya A. Vinnikov
The paper shows that miR-290-295 cluster is selectively expressed in adult dopamine neurons, protecting them by preserving protein synthesis and preventing locomotor deficits.
bioRxiv · Aug 5, 2025 · PreprintNeuroscience