Andrii Domanskyi

The paper shows that miR-290-295 cluster is selectively expressed in adult dopamine neurons, protecting them by preserving protein synthesis and preventing locomotor deficits.

The paper shows that PKB/AKT activation protects dopamine neurons from ER stress and -syn aggregation via Cathepsins B and D, suggesting a potential gene therapy approach for Parkinson's disease.

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

This study shows that activating the GDNF/RET signaling pathway prevents Lewy Body pathology in dopamine neurons by blocking α-synuclein aggregation.

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.