From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT
Jing Huang, Xueqi Shen, Yoland Smith, Lara Rabih Harik, Linghua Wang, J L Yu, Michael P. Epstein, Jian Hu
HiCAT improves spatial omics annotation by combining unsupervised clustering with atlas guidance, revealing molecularly defined regions and enhancing downstream analysis.
bioRxiv · May 31, 2026 · PreprintGenomics