Author

Jian Hu

Emory University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:spatial transcriptomics· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:machine learning (classical)· 2

Frequent Co-Authors

Aron S. BuchmaniD· 2 shared David Alan BennettiD· 2 shared Jingjing YangiD· 2 shared Michael P. EpsteiniD· 2 shared Philip L. De JageriD· 2 shared Atsushi MiyamotoiD· 1 shared Bing YaoiD· 1 shared Brett A. KaufmaniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Aron S. BuchmanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multimodal Analysis of Transcriptional Regulation in the Dorsolateral Prefrontal Cortex Enhances Alzheimer's Disease Risk Gene Discovery

Kyurhi Kim, Qiang Liu, Aron S. Buchman, Shinya Tasaki, David Alan Bennett, Yanling Wang, Philip L. De Jager, Jian Hu, Jingjing Yang, Michael P. Epstein

This study uses multimodal transcriptomic data to enhance Alzheimer's disease risk gene discovery, identifying 161 risk genes with proteomic support and an interconnected network of hub genes.

medRxiv · Nov 1, 2026 · PreprintGenetic & Genomic Medicine

Epithelial QKI Protects Against Emphysema by Maintaining Mitochondrial Integrity

Kiyoshi Uemasu, Kazuya Tanimura, Atsushi Miyamoto, Koichi Hasegawa, Zachary Lane, Reika Nyunoya, Haruka Uemasu, Brett A. Kaufman, Corrine R. Kliment, Divay Chandra, Frank C. Sciurba, Charles S. Dela Cruz, Prithu Sundd, Jonathan K. Alder, Jian Hu, Toru Nyunoya

This study identifies QKI as a regulator of mitochondrial integrity in COPD, showing its protective role against emphysema through maintenance of mitochondrial function.

bioRxiv · Jul 10, 2026 · PreprintCell Biology

From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT

Jing Huang, Xueqi Shen, Yoland Smith, Lara Rabih Harik, Linghua Wang, J L Yu, Michael P. Epstein, Jian Hu

HiCAT improves spatial omics annotation by combining unsupervised clustering with atlas guidance, revealing molecularly defined regions and enhancing downstream analysis.

bioRxiv · May 31, 2026 · PreprintGenomics

Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes

Shizhen Tang, Shihan Liu, Aron S. Buchman, David Alan Bennett, Philip L. De Jager, Jingjing Yang, Jian Hu

This study integrates spatial transcriptomics and snRNA-seq data to improve differential gene expression analysis of AD-related phenotypes, identifying novel genes and pathways not detectable with traditional methods.

Human Genetics and Genomics Advances · May 5, 2025Peer-reviewedGenetic & Genomic Medicine

Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT

Chenyang Yuan, Krupa Patel, Hongshun Shi, Hsiao‐Lin V. Wang, Feng Wang, Rong-Hua Li, Yangping Li, Victor G. Corces, Hailing Shi, Sulagna Das, Jindan Yu, Peng Jin, Bing Yao, Jian Hu

The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.

bioRxiv · Mar 27, 2025 · PreprintBioinformatics