Tripeptidyl peptidase II is essential for maintaining cerebrovascular homeostasis of female mice and represents a novel therapeutic target for vascular dementia
Jin Zhao, Qing Guo, Xiaohong Xin, Yujie Zhang, Kaixuan Pei, Junyao Li, Gang Wang, Jinghui Li, Wanqi Sun, Sai Huang, Xueyu Fan, Linlin Luo, Wen Li, Yuqi Wang, Yuanyuan Cao, , Jisen Huai
This study identifies TPP2 as essential for cerebrovascular homeostasis in female mice, linking its deficiency to vascular degeneration and cognitive impairment, and suggests Far1 as a therapeutic target.
bioRxiv · May 8, 2026 · PreprintNeuroscience