Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition.
Antoine Baudin, Hoang H. Dinh, Kira Breunig, Xuifen Lei, Xiaoping Xu, Luiz O. F. Penalva, David S. Libich
This paper identifies SERBP1 as a G4-binding protein that regulates translation through topology-driven recognition of G-quadruplex structures in RNA, with implications for cancer therapy.
bioRxiv · Mar 5, 2026 · PreprintBiophysics