Xiaoping Xu

BRCA1 promotes homologous recombination through separable DNA and RAD51 binding activities within its disordered region.

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition.

This paper identifies SERBP1 as a G4-binding protein that regulates translation through topology-driven recognition of G-quadruplex structures in RNA, with implications for cancer therapy.

Molecular Basis of EWS Interdomain Self-Association and Its Role in Condensate Formation

This paper investigates how EWS's RNA-binding domains interact with its low-complexity domain to influence condensate formation, revealing electrostatic and residue-specific interactions that underlie EWS self-association.

Characterization of heterogeneity in nanodisc samples using Feret signatures

This paper introduces an in-silico method using Feret signatures to characterize nanodisc samples, enabling the identification of low-heterogeneity preparations for accurate structure determination of membrane proteins.