Surf2Spot: A Surface-Informed Geometry-Aware Model for Predicting Binder and Nanobody Design Hotspots
Anwen Zhao, Yu Li, Tianhao Wu, Ran Fu, Zixuan Wang, Yanfen Xu, Xuliang Han, Yuxuan Lou, Wenying Wang, Jun Yan, Xiangfeng Wang
Surf2Spot predicts protein-protein and nanobody-antigen interaction hotspots using a deep learning model that integrates sequence, structure, and surface properties, improving performance over existing methods.
bioRxiv · Jan 25, 2026 · PreprintBioinformatics