Jun Yan

HalluCodon enables species-specific codon optimization using multimodal language models

HalluCodon designs species-specific coding sequences using multimodal language models trained on plant omics data, generating codons that match host-specific usage and support high expression.

Surf2Spot: A Surface-Informed Geometry-Aware Model for Predicting Binder and Nanobody Design Hotspots

Surf2Spot predicts protein-protein and nanobody-antigen interaction hotspots using a deep learning model that integrates sequence, structure, and surface properties, improving performance over existing methods.

Altered auditory maturation in Fragile X syndrome and its involvement in audiogenic seizure susceptibility

This study examines auditory maturation and audiogenic seizure susceptibility in Fmr1 knockout mice, finding hyperexcitability and altered brainstem responses linked to seizures.

Early developmental characterization of gap-induced prepulse inhibition and habituation in the Fragile X Syndrome mouse model

This study evaluates gap-induced prepulse inhibition and habituation in FMR1-KO mice during early development, finding sex differences and developmental changes in auditory responses.

Reproducible abnormalities of functional gradient reliably predict clinical and cognitive symptoms in schizophrenia

The paper identifies reproducible functional gradient abnormalities in schizophrenia that correlate with clinical and cognitive symptom severity using resting-state fMRI data.

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.