BioinformaticsbioRxivPreprint
Surf2Spot: A Surface-Informed Geometry-Aware Model for Predicting Binder and Nanobody Design Hotspots
Anwen Zhao, Yu Li, Tianhao Wu…·Xiangfeng Wang
Surf2Spot predicts protein-protein and nanobody-antigen interaction hotspots using a deep learning model that integrates sequence, structure, and surface properties, improving performance over existing methods.
DOI 10.64898/2026.01.23.700806