Author

Xun Gu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

David W. McCauley· 1 shared Gangbiao Liu· 1 shared Howard T. Hallmark· 1 shared James P. B. Lloyd· 1 shared Jeffrey A Haltom· 1 shared Jingqi Zhou· 1 shared Weiming Li· 1 shared Yangyun Zhou· 1 shared

Activity by Year

2015-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperEvolutionary Biology

David W. McCauley

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3 papers

Recent·Most cited

Case study: Paralog diverged features may help reduce off-target effects of drugs

Zhining Sa, Jingqi Zhou, Yangyun Zou, Xun Gu

This study identifies type-II functional divergence sites between paralogs to improve drug specificity and reduce off-target effects.

bioRxiv · Sep 28, 2016 · PreprintBioinformatics

Tissue-Driven Hypothesis of Transcriptome Evolution: An Update

Howard T. Hallmark, Jeffrey A Haltom, Xun Gu

This paper updates the tissue-driven hypothesis of transcriptome evolution by addressing the role of tissue-specific functional constraints and mutational variances using reanalysis of microarray data.

bioRxiv · May 24, 2016 · PreprintGenetics

Genome-wide and single-base resolution DNA methylomes of the Sea Lamprey (Petromyzon marinus) Reveal Gradual Transition of the Genomic Methylation Pattern in Early Vertebrates

Zhao Zhang, Gangbiao Liu, Yangyun Zhou, James P. B. Lloyd, David W. McCauley, Weiming Li, Xun Gu, Zhixi Su

This study reports the genome-wide DNA methylation patterns in the sea lamprey, revealing an intermediate methylation state between invertebrates and jawed vertebrates.

bioRxiv · Nov 30, 2015 · PreprintEvolutionary Biology