Telomere 3'-overhang attrition and persistent telomeric DNA damage response in failing human hearts
Bo Ye, Liang Shang, Xun Yuan, Yuyong Xu, Ying Wen, Yongying Shi, Haodong Xu, Xuejun Wang, Kenneth B. Margulies, Xiaojing Wang, Faqian Li
The paper investigates telomere dysfunction in failing human hearts, finding 3'-overhang attrition and DNA damage responses in cardiomyocytes from idiopathic dilated cardiomyopathy and ischemic heart disease.
bioRxiv · Aug 12, 2025 · PreprintMolecular Biology