TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice
Y. J. Sun, G. Velez, D. Parsons, K. Li, M. Ortiz, S. Sharma, P. B. McCray, A. G. Bassuk, V. B. Mahajan
The paper identifies structurally similar protease inhibitors for TMPRSS2, showing Avoralstat reduces SARS-CoV-2 infection in mice.
bioRxiv · Jan 4, 2021Microbiology