Author

M. Ortiz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Microbiology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

H. Salahshoor· 2 shared M. G. Shapiro· 2 shared A. B. Meier· 1 shared A. Dervan· 1 shared A. Eggert· 1 shared A. G. Bassuk· 1 shared A. G. Henssen· 1 shared A. Goedel· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

H. Salahshoor

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity

C. Broeker, M. Ortiz, M. Murillo, E. Andrechek

This study uses multi-omic sequencing to show the MMTV-Myc mouse model mirrors human breast cancer heterogeneity through conserved genomic and transcriptional features.

bioRxiv · Mar 28, 2023Cancer Biology

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

F. F. Pusch, H. Dorado Garcia, R. Xu, D. Gürgen, Y. Bei, L. Brückner, C. Röefzaad, J. von Stebut, V. Bardinet, M. d. R. Chamorro Gonzalez, A. Eggert, J. H. Schulte, P. Hundsdörfer, G. Seifert, K. Haase, , A. G. Henssen

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology

Application of Data-Driven computing to patient-specific simulation of brain neuromodulation

H. Salahshoor, M. Ortiz

The paper introduces data-driven solvers for simulating brain neuromodulation using patient-specific imaging data without analytical modeling.

bioRxiv · Sep 1, 2022 · PreprintBiophysics

Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

D. Zawada, J. Kornherr, A. B. Meier, G. Santamaria, T. Dorn, D. Ortmann, M. Lachmann, M. Ortiz, S. C. Harmer, M. Nobles, A. Tinker, R. A. Pedersen, P. Grote, K.-L. Laugwitz, A. Moretti, A. Goedel

This study shows that modulating retinoic acid signaling in human pluripotent stem cells generates heart field-specific progenitors, including a novel juxta-cardiac field, and identifies transcriptional dysregulation in a patient with hypoplastic left heart syndrome.

bioRxiv · May 30, 2022Cell Biology

TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice

Y. J. Sun, G. Velez, D. Parsons, K. Li, M. Ortiz, S. Sharma, P. B. McCray, A. G. Bassuk, V. B. Mahajan

The paper identifies structurally similar protease inhibitors for TMPRSS2, showing Avoralstat reduces SARS-CoV-2 infection in mice.

bioRxiv · Jan 4, 2021Microbiology

A genome compendium reveals diverse metabolic adaptations of Antarctic soil microorganisms

M. Ortiz, P. M. Leung, G. Shelley, M. W. Van Goethem, S. K. Bay, K. Jordaan, S. Vikram, I. D. Hogg, T. P. Makhalanyane, S. L. Chown, R. Grinter, D. A. Cowan, C. Greening

This study identifies diverse metabolic adaptations of Antarctic soil microorganisms using metagenomic analysis and experimental validation.

bioRxiv · Aug 6, 2020 · PreprintMicrobiology

Transcranial Focused Ultrasound Generates Skull-Conducted Shear Waves: Computational Model and Implications for Neuromodulation

H. Salahshoor, M. G. Shapiro, M. Ortiz

This study models shear wave propagation in the human skull caused by transcranial focused ultrasound and shows it can affect off-target structures like the cochlea.

bioRxiv · Apr 16, 2020Biophysics

Selective Ablation of Cancer Cells with Low Intensity Pulsed Ultrasound

D. R. Mittelstein, J. Ye, E. F. Schibber, A. Roychoudhury, S. L. Troyas, M. H. Fekrazad, M. Ortiz, P. P. Lee, M. G. Shapiro, M. Gharib

This study demonstrates that low intensity pulsed ultrasound selectively disrupts cancer cells by exploiting their distinct mechanical properties, offering a safer alternative to high intensity ultrasound ablation.

bioRxiv · Oct 1, 2019Bioengineering

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 As Marker of Aggressive Disease

M. J. Mason, C. Schinke, C. Eng, F. Towfic, F. Gruber, A. Dervan, B. S. White, A. Pratapa, Y. Guan, H. Chen, Y. Cui, B. Li, T. Yu, E. Chaibub Neto, K. Mavrommatis, , J. A. Guinney

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

bioRxiv · Aug 22, 2019Cancer Biology