The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction.
Y. Kyriukha, M. B. Watkins, J. M. Redington, R. Dastvan, V. N. Uversky, J. B. Hopkins, N. Pozzi, S. Korolev
This study identifies the PALB2 DNA-binding domain as an intrinsically disordered region that promotes DNA compaction through oligomerization, revealing a novel strand exchange mechanism.
bioRxiv · Jun 1, 2023Biophysics