High pressure inhibits signaling protein binding to the flagellar motor and bacterial chemotaxis through enhanced hydration
H. Hata, Y. Nishihara, M. Nishiyama, Y. Sowa, I. Kawagishi, A. Kitao
This study investigates how high pressure affects CheYp-FliM binding in E. coli chemotaxis using molecular dynamics and microscopy, finding that pressure weakens binding by ~10 kcal/mol and inhibits motor reversal.
bioRxiv · Sep 9, 2019Biophysics