SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties
V. Zakharova, M. Magnitov, L. Del-Maestro, S. Ulianov, A. Glentis, B. Ulyanik, A. Williart, A. Karpukhina, O. Demidov, V. Joliot, Y. Vassetzky, R.-M. V. Mege, M. Piel, S. Razin, S. Ait-Si-Ali
This study shows that SETDB1 loss-of-function in lung cancer cells alters chromatin structure, nuclear mechanics, and gene expression, reversing oncogenic properties.
bioRxiv · Sep 6, 2021Cancer Biology