Author

S. Ait-Si-Ali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Assay:ChIP-seq· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. LE GRAND· 2 shared V. JOLIOT· 2 shared A. BIGOT· 1 shared A. Glentis· 1 shared A. GRANADOS· 1 shared A. Karpukhina· 1 shared A. Williart· 1 shared B. Ulyanik· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

F. LE GRAND

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SETDB1 modulates the TGFbeta response in Duchenne muscular dystrophy myotubes

A. GRANADOS, M. ZAMPERONI, R. RAPONE, M. MOULIN, E. BOYARCHUK, C. BOUYIOUKOS, L. DEL MAESTRO, V. JOLIOT, E. NEGRONI, M. MOHAMED, S. PIQUET, A. BIGOT, F. LE GRAND, S. ALBINI, S. AIT-SI-ALI

This study shows that SETDB1 enhances TGFβ-driven fibrosis in DMD myotubes by modulating TGFβ-target gene expression and secretome effects on myoblast differentiation.

bioRxiv · Jun 28, 2023Cell Biology

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

P. Garcia, W. Jarassier, C. Brun, L. Giordani, F. Agostini, W. H. Kung, C. Peccate, J. Ravent, S. Fall, V. Petit, T. Cheung, S. Ait-Si-Ali, F. Le Grand

This study shows that Setdb1 in muscle stem cells prevents endogenous retrovirus activation and maintains genome stability, which is essential for muscle regeneration and inflammation control.

bioRxiv · Jun 8, 2023 · PreprintCell Biology

SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties

V. Zakharova, M. Magnitov, L. Del-Maestro, S. Ulianov, A. Glentis, B. Ulyanik, A. Williart, A. Karpukhina, O. Demidov, V. Joliot, Y. Vassetzky, R.-M. V. Mege, M. Piel, S. Razin, S. Ait-Si-Ali

This study shows that SETDB1 loss-of-function in lung cancer cells alters chromatin structure, nuclear mechanics, and gene expression, reversing oncogenic properties.

bioRxiv · Sep 6, 2021Cancer Biology