Single-cell transcriptome analysis reveals TOX as a promoting factor for T-cell exhaustion and a predictor for anti-PD1 responses in human cancer
K. Kim, S. Park, S. Y. Park, G. Kim, S. M. Park, J.-W. Cho, D. H. Kim, Y. M. Park, Y. W. Koh, H. R. Kim, S.-J. Ha, I. Lee
The paper identifies TOX as a factor promoting T-cell exhaustion and predicts its role in anti-PD1 therapy outcomes using single-cell transcriptome data from cancer patients.
bioRxiv · Dec 3, 2019 · PreprintCancer Biology