D. H. Kim

Spatiotemporal 4D Whole-cell Modeling of a Minimal Autotroph Reveals Central Carbon Metabolism Regulated Locally by Protein Megacomplexes via Post-translational Modifications under Light Disturbance

The paper develops a 4D whole-cell model of Prochlorococcus marinus MED4 to show how spatial organization and redox PTMs regulate carbon fixation under light disturbance.

Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage

The paper integrates AMGs and phage assembly into a genome-scale metabolic model to predict their impact on host metabolism and phage production, revealing synergistic and antagonistic effects.

Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability

This study evaluates the quality and suitability of long-term stored tissues for multi-omics analyses, showing that while transcriptomic data show some changes, core gene expression and proteomic measurements remain reliable.

Bacteria Are a Major Determinant of Orsay Virus Transmission and Infection in Caenorhabditis elegans

This study shows that specific bacteria can significantly influence Orsay virus transmission and host susceptibility in C. elegans.

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

This study shows indoxyl sulfate induces trained immunity in monocytes via AhR-dependent arachidonic acid pathway, contributing to inflammation in ESRD.

Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions

The paper investigates apoptosis in hepatocytes during colorectal cancer liver metastasis and finds that cancer cells induce hepatocyte apoptosis to replace them in co-opted lesions.

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

Designing Topographically Textured Microparticles For Induction and Modulation of Osteogenesis in Mesenchymal Stem Cell Engineering

This study shows that topographically textured microparticles can enhance osteogenic markers in mesenchymal stem cells without exogenous factors.

Single-cell transcriptome analysis reveals TOX as a promoting factor for T-cell exhaustion and a predictor for anti-PD1 responses in human cancer

The paper identifies TOX as a factor promoting T-cell exhaustion and predicts its role in anti-PD1 therapy outcomes using single-cell transcriptome data from cancer patients.

Global transcriptional regulation of innate immunity in C. elegans

The paper identifies ATF-7 as a key transcriptional regulator of the innate immune response in C. elegans through genomic analysis of pathogen-induced gene regulation.

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.