BET Inhibitors Target the SCLC-N subtype Small Cell Lung Cancer by Blocking NEUROD1 Transactivation
H. Chen, L. Gesumaria, Y.-K. Park, T. G. Oliver, D. S. Singer, K. Ge, D. S. Schrump
This study identifies BET bromodomain proteins as coactivators of NEUROD1 in SCLC, showing that BET inhibitors suppress NEUROD1-target genes and reduce tumor growth.
bioRxiv · Oct 25, 2021Cancer Biology