Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level
Tianyu Liu, Teng Cai, Junfeng Huo, Hongwei Liu, Aiying Li, Meng Jie Yin, Yan Mei, Yueyue Zhou, Sijun Fan, Yao Lu, Luo-Sheng Wan, Huijuan You, Xiaofeng Cai
This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.
Nucleic Acids Research · Aug 28, 2024Peer-reviewedBiophysics