Fibrotic lung-derived sphingosine-1-phosphate drives emotion-like disorders by regulating hippocampal neuroinflammation and cell death
Zhihao Xu, Xu Deshang, Keqin Liu, Yang Yijia, Han Xingjie, Fen Yang, Nan Wenbin, Jiang Du, Guo Rui, Yonghai Li, Ping Zhang, Yanli Liu, Juntang Lin
This study shows that S1P from fibrotic lungs causes neuroinflammation and mood disorders by acting on the hippocampus, and inhibiting S1P pathways can alleviate these effects.
Journal of Neuroinflammation · Sep 16, 2026Peer-reviewedNeuroscience