Ping Zhang

Fibrotic lung-derived sphingosine-1-phosphate drives emotion-like disorders by regulating hippocampal neuroinflammation and cell death

This study shows that S1P from fibrotic lungs causes neuroinflammation and mood disorders by acting on the hippocampus, and inhibiting S1P pathways can alleviate these effects.

High-Precision Pneumatic Induction of Traumatic Brain Injury in Larval Zebrafish

This paper introduces a high-precision pneumatic device for inducing traumatic brain injury in larval zebrafish, showing improved reproducibility and consistent injury severity measurements.

Proteome-wide reverse molecular docking reveals folic acid receptor as a mediator of PFAS-induced neurodevelopmental toxicity

This study identifies folic acid receptor beta as a mediator of PFAS-induced neurodevelopmental toxicity using zebrafish models and reverse molecular docking.

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

The paper shows that butyrate rescues CPF-induced social deficits in zebrafish by inhibiting class I HDACs, linking CPF exposure to gut microbiome, metabolome, and epigenetic changes.

The somato-cognitive action network links diverse neuromodulatory targets for Parkinson's disease

This study identifies the somato-cognitive action network (SCAN) as a key pathway in Parkinson's disease, showing its dysfunction and link to neuromodulatory treatments.

Single-cell analysis reveals a pathogenic cellular module associated with early allograft dysfunction after liver transplantation

The paper constructs a single-cell transcriptomic atlas of transplanted livers and identifies an EAD-associated pathogenic cellular module.

A single-cell transcriptomic atlas characterizes liver non-parenchymal cells in healthy and diseased mice

The paper constructs a single-cell transcriptomic atlas of liver non-parenchymal cells in healthy and diseased mice, identifying disease-specific heterogeneity and functional changes.

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

This paper develops an siRNA-nanoparticle therapy targeting SARS-CoV-2 that reduces viral load and improves survival in mice.

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.