Empagliflozin alleviates doxorubicin-induced cardiotoxicity by suppressing oxidative stress via modulation of the JNK/Nrf2 signaling pathway
Guangquan Peng, Lihua Ni, Ziyang Guo, Liwen Huang, Wanqing Ma, Fuchun Zheng, Yanmei Zhang, 高凤飞 GAO Fengfei, Zhen Wang, WenFeng Cai
This study shows empagliflozin reduces doxorubicin-induced cardiotoxicity by modulating the JNK/Nrf2 pathway and decreasing oxidative stress in mice.
bioRxiv · Jan 5, 2026 · PreprintPharmacology & Toxicology