Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis
Luting Yang, Chunqing Hu, Xiaowen Chen, Jie Zhang, Zhe Feng, Yanxin Xiao, Weitai He, Tingting Cui, Xin Zhang, Yang Yang, Yaling Zhang, Yaping Yan
This study identifies TRIM21-mediated ubiquitination promoting PKM2 nuclear translocation and astrocyte activation in EAE, suggesting a therapeutic target for neurological diseases.
eLife · Jun 14, 2024Peer-reviewedNeuroscience