Xiaowen Chen

Genomic Insights into Hybridization and Speciation of Mitten Crabs in the Eriocheir Genus

The paper analyzes whole genome data from seven Eriocheir populations to reveal hybridization history and genomic adaptations in mitten crabs, identifying divergent selection and selective sweeps in reproductive genes.

YAP/TAZ signaling in allantois-derived cells is required for placental vascularization

This study shows that YAP/TAZ signaling in allantois-derived cells is essential for placental vascularization, as its loss causes embryonic lethality and vascular defects.

Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

This study identifies TRIM21-mediated ubiquitination promoting PKM2 nuclear translocation and astrocyte activation in EAE, suggesting a therapeutic target for neurological diseases.

Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML

The paper develops a computational approach to model core gene regulatory networks in IDH mutant AML, identifying key regulators like DNMT1 and E2F1 supported by patient survival data.

Tissue-expression profiles unveils the gene interaction of hepatopancreas, eyestalk, and ovary in precocious female Chinese mitten crab, Eriocheir sinensis

The paper identifies gene interactions in hepatopancreas, eyestalk, and ovary tissues of precocious female Chinese mitten crabs, revealing their roles in vitellogenesis and sexual development.