Jie Zhang

Efferocytosis Remodels Osteoclast Metabolism and Enhances Antibacterial Defense

This study shows that osteoclast efferocytosis enhances antibacterial defense by remodeling metabolism through glycolytic activity and lactate handling.

A 21-Color Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Rat Tissues and a Companion 9-Color T-Cell Functional Assay

Ourotide: decoding the hierarchical peptide recognition for generative design

The paper introduces Ourotide, a deep learning framework for peptide recognition that outperforms generalist models by capturing a unique hierarchical binding mode through physics-guided data augmentation.

Neurokinin 1 receptor blockade is associated with increased survival of patients with C. difficile infection

This study shows that blocking the Neurokinin 1 receptor with antagonists improves survival in C. difficile infection patients and reduces vascular inflammation.

Selective Immune Silencing by Targeted TGF-β Mimics

This paper develops TGF-β agonists targeting specific T and B cells to selectively suppress pathogenic immune responses in autoimmune and inflammatory diseases.

Nocturnal pollination services as an ecological safety net for papaya production in a tropical biodiversity hotspot

The paper evaluates the contributions of diurnal and nocturnal pollinators to papaya yields in Kenya, finding additive services and highlighting the importance of nocturnal pollinators under organic management.

IL-21-producing peripheral helper T cells associate with autoimmune bile duct injury in biliary atresia

This study identifies IL-21-producing Tph cells in tertiary lymphoid structures of biliary atresia patients and shows IL-21R blockade reduces disease severity in a mouse model.

Ecosystem disservices are underrepresented in literature on annual crop agroecosystems

The paper identifies a systematic underrepresentation of ecosystem disservices in literature on annual crop agroecosystems, highlighting biases in how agroecosystem functioning is understood.

Spatiotemporal Transcriptomic Dissection Uncovers Age-Dependent Deceleration of Esophageal Cell Differentiation

This study uses single-cell transcriptomics to analyze age-related changes in esophageal stem cell dynamics and differentiation, finding that impaired differentiation, not stem cell self-renewal, drives aging-related homeostasis decline.

Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing Ferroptosis

This study shows that TP53-deficient tumors resist DS-7300a therapy, but inducing ferroptosis can enhance its efficacy in these cancers.

Plasma proteomics reveal heterogeneous subtypes of depression linked to inflammation and aging

The paper identifies three depression subtypes using plasma proteomics, linked to inflammation, aging, and metabolic factors, with distinct clinical and neurobiological features.

Multi-omics analysis of the potential of MACC1 as a biomarker and therapeutic target for colonic adenocarcinoma

This study analyzes MACC1 expression and its associations in colonic adenocarcinoma using public datasets, suggesting it as a potential biomarker and therapeutic target.

Graph pangenome reveals structural variation dynamics during cucumber breeding

The paper constructs a cucumber pangenome to analyze structural variant dynamics during domestication and breeding, finding SVs are purged more than SNPs and improving genomic prediction accuracy.

NFATc3 enhances DREAM complex-driven tumorigenesis

This study identifies NFATc3's role in promoting DREAM complex-driven tumorigenesis in lung adenocarcinoma by enhancing target gene transactivation.

Disrupted dynamics of brain structure function coupling link genetic risk of Alzheimer's Disease and aging to cognitive decline in 34,067 adults

The paper examines how static and dynamic structure-function coupling in the brain relates to cognitive decline and Alzheimer's risk in 34,067 adults.

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

This study identifies CDK inhibitor-sensitive cells-of-origin in ESCC using single-cell trajectory analysis and drug repurposing, revealing key regulators and therapeutic vulnerabilities.

Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics

This study uses genetic barcoding and single-cell transcriptomics to trace lineage dynamics of esophageal preneoplastic cells, identifying a high-plasticity progenitor population and molecular markers for early detection of esophageal squamous cell cancer.

Visuospatial attention exerts opposite modulatory effects on explicit and implicit audiovisual subjective synchrony via the frontoparietal network

This study investigates how visuospatial attention modulates explicit and implicit audiovisual synchrony through distinct neural mechanisms, showing opposite effects on their behavioral and oscillatory correlates.

Comparative single-cell transcriptomics of orthotopic and subcutaneous gastric tumors reveal immune and stromal heterogeneity

This study compares immune and stromal differences between orthotopic and subcutaneous gastric tumors using scRNA-seq, finding distinct TME features in each model.

Electric fields trigger ceramide-dependent budding of exosome vesicles into multivesicular endosomes and boost the generation of exosomes

This paper shows electric fields boost exosome production by 100-fold through ceramide-dependent mechanisms, offering a new method for exosome generation.

A Novel Optimized Silver Nitrate Staining Method for Visualizing the Osteocyte Lacuno-Canalicular System

This paper introduces an optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system, showing improved staining consistency and LCS detection across species.

Variation analysis of fruit phenotypic traits of different provenances of ancient Cinnamomum camphora in Jiangxi Province of China

This study analyzes fruit phenotypic variation in ancient Cinnamomum camphora across Jiangxi Province, finding significant variation among provenances and correlations with geographic and climate factors.

Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

This study identifies TRIM21-mediated ubiquitination promoting PKM2 nuclear translocation and astrocyte activation in EAE, suggesting a therapeutic target for neurological diseases.

A neural signature for the subjective experience of threat anticipation under uncertainty

The paper develops a neural signature that predicts anxious arousal during uncertain threat anticipation using fMRI and multivariate modeling.

RNA G-quadruplex structure contributes to cold adaptation in plants

The paper identifies G-quadruplex structures in cold-adapted plants, showing they enhance mRNA stability and improve cold response.

FEDERATED MORPHOMETRY FEATURE SELECTION FOR HIPPOCAMPAL MORPHOMETRY ASSOCIATED BETA-AMYLOID AND TAU PATHOLOGY

This paper introduces FMFS, a framework for selecting hippocampal morphometry features linked to Aβ/tau pathology, showing it outperforms existing methods and identifies key subregions for biomarker development.

MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism

The paper identifies shared circuit-level abnormalities between MECP2 transgenic monkeys and a subgroup of human autism patients, highlighting the need for a multimodal approach to study genetic effects in a primate model.

Decreased green autofluorescence intensity of lung parenchyma is a potential non-invasive diagnostic biomarker for lung cancer

Characterization of a Novel Model of Overuse-Induced Calcific Achilles Tendinopathy in Mice: Contralateral Tendinopathy Following Unilateral Tenotomy

This paper develops a mouse model of overuse-induced calcific Achilles tendinopathy by inducing unilateral tenotomy and observing contralateral tendon pathology after 12 weeks.