NF-kB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly by P450scc/SOD2 deacetylation
Mei Wang, Ling Zeng, Yao Xiong, Xiaofei Wang, Lin Cheng, Fang Wang, Ping Su, Yuanzhen Zhang
This study shows that Sirt3, repressed by NF-kB, regulates cholesterol metabolism and cytoskeleton assembly in testicular cells through P450scc/SOD2 deacetylation, affecting spermatogenesis and male fertility.
bioRxiv · Feb 22, 2021 · PreprintDevelopmental Biology