Developmental BiologybioRxivPreprint
NF-kB-repressed Sirt3 mediates testicular cholesterol metabolism and cytoskeleton assembly by P450scc/SOD2 deacetylation
Mei Wang, Ling Zeng, Yao Xiong…·Yuanzhen Zhang
This study shows that Sirt3, repressed by NF-kB, regulates cholesterol metabolism and cytoskeleton assembly in testicular cells through P450scc/SOD2 deacetylation, affecting spermatogenesis and male fertility.