mRNA 3'UTRs chaperone intrinsically disordered regions to control protein activity
Yang Luo, Yaofeng Zhong, Sudipto Basu, Ming-Chung Wu, Christine Mayr
The paper shows that mRNA 3'UTRs act as chaperones for intrinsically disordered regions (IDRs) to regulate protein activity by promoting IDR-IDR interactions and preventing domain folding interference.
Cell · Jun 8, 2026Peer-reviewedMolecular Biology