The paper shows that mRNA 3'UTRs act as chaperones for intrinsically disordered regions (IDRs) to regulate protein activity by promoting IDR-IDR interactions and preventing domain folding interference.

Cell · Jun 8, 2026Peer-reviewedMolecular Biology

Fully automated and integrated proteomics sample preparation platform for high-throughput drug target identification

Qiong Di Wu, Jiangnan Zheng, Xintong Sui, Changying Fu, Xiaozhen Cui, Bin Yih Liao, Hongchao Ji, Yang Luo, An He, Xue Mei Lu, Chris Soon Heng Tan, Ruijun Tian

The paper introduces an automated proteomics sample preparation platform that improves throughput for drug target identification.

bioRxiv · Jul 14, 2023 · PreprintSystems Biology

mRNA interactions with disordered regions control protein activity

Yang Luo, Supriya Pratihar, Ellen Horste, Sibylle Mitschka, Antonia S. J. S. Mey, Hashim M. Al‐Hashimi, Christine Mayr

The paper shows that mRNAs interact with disordered regions of proteins like MYC to control their activity by enabling specific protein complexes formed in translation sites called TIS granules.

bioRxiv · Feb 18, 2023 · PreprintMolecular Biology

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff

The paper identifies alt-RPL36 as a novel regulator of PI3K-AKT-mTOR signaling through interaction with TMEM24, showing its role in modulating PI(4,5)P2 levels and cell size.

Nature Communications · Jan 21, 2021Peer-reviewedGenomics