Adaptive immunity is dispensable for appendage regeneration in highly regenerative vertebrates
Lizbeth Airais Bolaños Castro, Yaswanth Othayoth Valappil, Andreas Petzold, Franziska Knopf, Maximina Hee Yun
This study shows that adaptive immune cells are not required for appendage regeneration in axolotls and zebrafish, with regeneration proceeding normally despite the absence of mature T and B cells.
bioRxiv · Apr 15, 2026 · PreprintImmunology