Functional dissection of SPOP on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis
Seong Kyun Park, Jeongha Lee, Seon Ju Park, Ye Na Kim, Gi Hyun Shin, Dohyun Han, Hee‐Jung Choi, Byung Joon Hwang, Murim Choi
The paper uses deep mutational screening to analyze SPOP variants, identifying loss-of-function variants enriched in prostate cancer and revealing their structural and genetic characteristics.
Proceedings of the National Academy of Sciences · May 6, 2026Peer-reviewedGenetics