GeneticsProceedings of the National Academy of SciencesPeer-reviewed
Functional dissection of SPOP on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis
Seong Kyun Park, Jeongha Lee, Seon Ju Park…·Murim Choi
The paper uses deep mutational screening to analyze SPOP variants, identifying loss-of-function variants enriched in prostate cancer and revealing their structural and genetic characteristics.
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