Dohyun Han

Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cells

This study develops dual-targeted lipid nanoparticles to enhance the ex vivo generation of CAR-T cells and CAR-monocytes, showing improved cytotoxic and phagocytic activity.

Ubiquitin Receptor-Induced Proximity is Sufficient for Ubiquitin-Independent Targeted Protein Degradation via the 26S Proteasome

This paper introduces Protea-Tac, a Ub-independent protein degrader that targets proteins to the proteasome, demonstrating in vivo tumor suppression.

Chemical N-degrons activate p62-mediated mitophagy to alleviate mitochondrial neuropathies

This study identifies ATB1071, a compound that activates p62-mediated mitophagy through Arg/N-degrons, showing therapeutic benefits in mitochondrial neuropathies and ischemia-reperfusion injury.

Functional dissection of SPOP on the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis

The paper uses deep mutational screening to analyze SPOP variants, identifying loss-of-function variants enriched in prostate cancer and revealing their structural and genetic characteristics.

Metabolic signals regulate resuscitation speed of antibiotic persister bacteria during infection

The paper shows that L-serine speeds up and arginine slows down the awakening of antibiotic persisters, offering new targets for treating chronic infections.

Regularized Deep Neural Networks for Combining Heterogeneous Features of Peptides in Data Independent Acquisition Mass Spectrometry

This paper introduces a deep learning model for generating spectral libraries in DIA-MS by incorporating physicochemical features and sparsity regularization, outperforming existing models in retention time prediction and peptide identification.

De novo HDAC3 variants leading to epigenetic machinery dysfunction are associated with a neurodevelopmental disorder

This study identifies de novo HDAC3 variants in patients with neurodevelopmental disorders and shows they cause reduced HDAC activity, disrupted protein interactions, and impaired nuclear localization.

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

This study identifies 91 differentially expressed plasma proteins between severe and non-severe COVID-19 patients, highlighting potential biomarkers and therapeutic targets.

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

This study identifies Nedd4 and beta-arrestins as regulators of mGlu7 ubiquitination, trafficking, and degradation in neurons.