Protecting synapses from amyloid β-associated degeneration by manipulations of Wnt/planar cell polarity signaling
Bo Feng, Andiara E. Freitas, Runyi Tian, Yeo Rang Lee, Akumbir S. Grewal, Jingyi Wang, Yimin Zou
The paper investigates how Aβ oligomers disrupt Wnt/PCP signaling by interacting with Celsr3 and Vangl2, leading to synapse loss in Alzheimer's disease, and suggests potential therapeutic strategies.
bioRxiv · Sep 9, 2020 · PreprintNeuroscience