IFN-gamma-Induced Intestinal Epithelial Cell-Type-Specific Programmed Cell Death: PANoptosis and Its Modulation in Crohn's Disease
Chansu Lee, Ji Eun Kim, Yeo-Eun Cha, Ji Hwan Moon, Eun Ran Kim, Dong Kyung Chang, Young Ho Kim, Sung Noh Hong
This study shows IFN-gamma induces PANoptosis in intestinal epithelial cells in Crohn's disease, which can be inhibited by the JAK1 inhibitor upadacitinib.
Frontiers in Immunology · Mar 31, 2025Peer-reviewedCell Biology