A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae
Jean-Christophe Boivin, Yi Q Zhao, Jiayi Zhu, Jared T. Dakin, Jing Ning, Tomoko Ohyama
The paper shows that repeated nociceptive stimulation in Drosophila larvae increases escape behavior through a positive feedback loop involving sensory and octopaminergic neurons.
PLoS Genetics · Apr 28, 2026Peer-reviewedNeuroscience