Htm1p-Pdi1p is a folding sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation
Yi-Chang Liu, Danica Galonić Fujimori, Jonathan S. Weissman
The paper identifies Htm1p-Pdi1p as a folding-sensitive mannosidase that specifically demannosylates misfolded N-glycoproteins for ERAD.
bioRxiv · Apr 22, 2016Biochemistry