Cytoskeleton remodeling caused by keratin dysregulation triggers tumor aggressiveness via promoting genomic instability and cellular adaption
Hsiang-Hao Chuang, Brian Yu-Ting Kuo, Kalpana Sriramadasu, Ming‐Tsung Lai, Leo Yen-Ting Lin, Yi-Che Chen, Preetham Kumar Boominathan, Tritium Hwang, Chih‐Mei Chen, Cherry Yin‐Yi Chang, Jim Jinn‐Chyuan Sheu
This study shows keratin fusion variants increase tumor aggressiveness by causing genomic instability, promoting drug resistance, and altering cytoskeleton structures.
bioRxiv · Nov 3, 2025 · PreprintCancer Biology