Genome-wide maps of transcription factor footprints identify noncoding variants rewiring gene regulatory networks
Jiecong Lin, Wenyang Dong, Jiaxiang Zhang, Chen Xie, Xiaoxi Jing, Junpeng Zhao, Kaiyan Ma, Hongen Kang, Yilin Jiang, Xiao Xie, Yajie Zhao
The paper identifies noncoding variants that alter gene regulatory networks using a combination of single-molecule deaminase footprinting and variant effect prediction, applied to UK Biobank genomes.
bioRxiv · Mar 25, 2026 · PreprintBioinformatics