Author

Wenyang Dong

Changping Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genomics· 2 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 3 Organism:human· 3 Research Focus:variant effect prediction· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jun ReniD· 3 shared Chen Xie· 2 shared Dubai LiiD· 2 shared Fanchong JianiD· 2 shared Jiankun ZhangiD· 2 shared Runsheng He· 2 shared Shuang LiuiD· 2 shared Xiaoliang Sunney XieiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Jun RenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prediction of Transcription Factor DNA Binding Affinity with High-Throughput Kd Measurements and Deep Learning

Zi Wang, Di Wang, Ke Shen, Junchen Luo, Xinyao Wang, Nan Wu, Yunzhi Lang, X Wang, Jun Ren, Wenyang Dong, Lu Pan, Yitong Lyu, Dubai Li, Chen Xie, Zhen Zhang, , Xiaoliang Sunney Xie

The paper introduces Seq2Kd, a deep learning model predicting TF-DNA binding affinity using high-throughput Kd measurements, and provides a web portal for functional genomics and disease research.

bioRxiv · May 20, 2026 · PreprintBiophysics

Genome-wide maps of transcription factor footprints identify noncoding variants rewiring gene regulatory networks

Jiecong Lin, Wenyang Dong, Jiaxiang Zhang, Chen Xie, Xiaoxi Jing, Junpeng Zhao, Kaiyan Ma, Hongen Kang, Yilin Jiang, Xiao Xie, Yajie Zhao

The paper identifies noncoding variants that alter gene regulatory networks using a combination of single-molecule deaminase footprinting and variant effect prediction, applied to UK Biobank genomes.

bioRxiv · Mar 25, 2026 · PreprintBioinformatics

Mapping eukaryotic chromatin accessibility and histone modifications with DNA deaminase

Wenyang Dong, Jiankun Zhang, Leyi Dai, Jinxin Phaedo Chen, Honggui Wu, Runsheng He, Yuxuan Pang, Zhi Wang, Fanchong Jian, Jun Ren, Yijun Liu, Yu Tian, Shuang Liu, Xuechen Zhao, Xiaoliang Sunney Xie

The paper introduces two new methods, ChrODIE and ANDIE, for mapping chromatin accessibility and histone modifications without enzymatic cleavage, enabling multi-omics integration.

bioRxiv · Dec 24, 2024 · PreprintGenomics

Human transcription factor combinations mapped by footprinting with deaminase

Runsheng He, Wenyang Dong, Zhi Wang, Chen Xie, Long Gao, Wenping Ma, Ke Shen, Dubai Li, Yuxuan Pang, Fanchong Jian, Jiankun Zhang, Yuan Yuan, Xinyao Wang, Zhen Zhang, Yinghui Zheng, , Xiaoliang Sunney Xie

The paper introduces a method to map transcription factor binding sites genome-wide with single-base resolution and applies it to study cell-type-specific TF cooperativity in human tissues.

Proceedings of the National Academy of Sciences · Dec 17, 2024Peer-reviewedGenomics